Periannan Kuppusamy Selected Research

nitroaspirin

2/2008	NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols.
1/2008	NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts.
11/2007	Nitroaspirin (NCX-4016), an NO donor, is antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothelial cells.
9/2006	Prevention of postischemic myocardial reperfusion injury by the combined treatment of NCX-4016 and Tempol.
3/2006	Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin.

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Periannan Kuppusamy Research Topics

Disease

70	Neoplasms (Cancer) 01/2022 - 01/2002
20	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 12/2005
20	Myocardial Infarction 07/2021 - 04/2002
18	Hypoxia (Hypoxemia) 09/2021 - 01/2005
18	Ischemia 01/2015 - 04/2002
17	Infarction (Infarctions) 11/2013 - 05/2006
10	Reperfusion Injury 11/2013 - 07/2005
8	Heart Failure 09/2021 - 01/2006
6	Cardiovascular Diseases (Cardiovascular Disease) 07/2021 - 01/2007
6	Myocardial Ischemia (Ischemic Heart Diseases) 01/2013 - 06/2006
5	Stroke (Strokes) 07/2021 - 07/2010
5	Wounds and Injuries (Trauma) 01/2021 - 11/2005
5	Cardiotoxicity 10/2015 - 12/2005
4	Hyperoxia 01/2021 - 11/2005
4	Mitochondrial Diseases (Mitochondrial Disease) 06/2020 - 04/2004
4	Neoplasm Metastasis (Metastasis) 01/2019 - 03/2009
4	Breast Neoplasms (Breast Cancer) 10/2015 - 03/2009
4	Carcinoma (Carcinomatosis) 11/2011 - 01/2008
4	Fibrosarcoma 05/2010 - 01/2002
3	Fibrosis (Cirrhosis) 01/2013 - 01/2012
3	Body Weight (Weight, Body) 11/2010 - 05/2002
2	Ovarian Epithelial Carcinoma 01/2022 - 07/2012
2	Pulmonary Hypertension 09/2021 - 03/2013
2	Adenocarcinoma 06/2020 - 03/2008
2	Pancreatic Neoplasms (Pancreatic Cancer) 06/2020 - 06/2019
2	Colonic Neoplasms (Colon Cancer) 03/2019 - 03/2008
2	Ischemic Stroke 12/2017 - 07/2010
2	Ascites 04/2014 - 12/2005
2	Vascular Remodeling 11/2013 - 06/2009
2	Myocardial Reperfusion Injury 01/2013 - 09/2006
2	Cicatrix (Scar) 01/2013 - 01/2011

Drug/Important Bio-Agent (IBA)

40	Oxygen (Dioxygen)IBA 01/2022 - 11/2003
19	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2008
14	(3,5- bis((4- fluorophenyl)methylidene)- 1- ((1- hydroxy- 2,2,5,5- tetramethyl- 2,5- dihydro- 1H- pyrrol- 3- yl)methyl)piperidin- 4- one)IBA 09/2021 - 06/2009
13	Cisplatin (Platino)FDA LinkGeneric 10/2016 - 03/2006
10	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2015 - 12/2005
10	AntioxidantsIBA 10/2015 - 05/2002
8	CurcuminIBA 01/2018 - 02/2007
8	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2013 - 10/2003
7	nitroxylIBA 06/2020 - 05/2002
7	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2015 - 12/2005
7	Caspase 3 (Caspase-3)IBA 01/2014 - 03/2008
7	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2014 - 03/2009
6	lithium phthalocyanineIBA 01/2014 - 10/2002
6	Superoxides (Superoxide)IBA 01/2013 - 02/2007
6	Pharmaceutical PreparationsIBA 11/2011 - 07/2005
5	Antineoplastic Agents (Antineoplastics)IBA 08/2011 - 01/2006
5	Free RadicalsIBA 12/2010 - 09/2004
5	nitroaspirinIBA 02/2008 - 03/2006
4	PlatinumIBA 01/2022 - 07/2012
4	lithium 5,9,14,18,23,27,32,36- octa- n- butoxy- 2,3- naphthocyanineIBA 01/2021 - 05/2007
4	PiperidonesIBA 03/2019 - 05/2010
4	EnzymesIBA 10/2015 - 10/2003
4	Therapeutic UsesIBA 07/2012 - 04/2002
4	MercuryIBA 05/2009 - 01/2007
4	CalciumIBA 05/2009 - 08/2007
4	Krebs-Henseleit solutionIBA 09/2007 - 01/2006
3	Paclitaxel (Taxol)FDA LinkGeneric 01/2018 - 11/2009
3	Phosphotransferases (Kinase)IBA 01/2018 - 03/2012
3	CaspasesIBA 10/2016 - 03/2008
3	carbogenIBA 01/2014 - 10/2002
3	alpha,beta-diacryloxypropionic acid (DAPS)IBA 05/2013 - 05/2010
3	NG-Nitroarginine Methyl Ester (L-NAME)IBA 01/2013 - 06/2005
3	Oxidants (Oxidizing Agents)IBA 01/2012 - 05/2002
3	pyrrolineIBA 08/2011 - 06/2006
3	Creatine Kinase (Creatine Phosphokinase)IBA 11/2010 - 05/2006
3	Glutathione (Reduced Glutathione)IBA 08/2008 - 01/2002
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2008 - 03/2006
3	p38 Mitogen-Activated Protein KinasesIBA 02/2007 - 05/2006
3	tempolIBA 09/2006 - 04/2002
3	Trimetazidine (Vastarel)IBA 08/2006 - 07/2005
2	L-2663IBA 01/2022 - 06/2020
2	Protein Isoforms (Isoforms)IBA 01/2019 - 10/2003
2	ErbB Receptors (EGF Receptor)IBA 01/2018 - 09/2010
2	Tyrosine (L-Tyrosine)FDA Link 10/2014 - 07/2012
2	Annexin A5IBA 01/2014 - 11/2013
2	TensinsIBA 11/2013 - 06/2009
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2013 - 06/2009
2	Peroxynitrous Acid (Peroxynitrite)IBA 03/2013 - 09/2007
2	Caspase 7IBA 07/2012 - 12/2010
2	ProteomeIBA 03/2012 - 01/2012
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 08/2010 - 11/2009
2	1-dodecylpyridoxal (PLD)IBA 05/2009 - 01/2007
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 04/2009 - 12/2007
2	Sulfaphenazole FDA Link 04/2009 - 12/2007
2	Verapamil (Calan)FDA LinkGeneric 01/2009 - 10/2007
2	triphenyltetrazoliumIBA 06/2008 - 12/2007
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 03/2008 - 06/2006
2	Biological ProductsIBA 11/2007 - 05/2002
2	arginine methyl esterIBA 09/2007 - 06/2005
2	BuffersIBA 09/2007 - 07/2005

Therapy/Procedure

27	Therapeutics 06/2020 - 01/2002
10	Drug Therapy (Chemotherapy) 01/2019 - 05/2002
6	Radiotherapy 07/2021 - 09/2004
4	Transplantation 12/2017 - 10/2007
3	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2013 - 10/2007
3	Stem Cell Transplantation 01/2013 - 01/2011
3	Ligation 10/2012 - 10/2007
3	Hyperbaric Oxygenation 08/2010 - 11/2005
2	Lasers (Laser) 07/2010 - 04/2010